Pilot Program

Ryniant Pilot

A paid, time-boxed deployment on one active small-molecule discovery program to translate tissue delivery goals into executable DMTA workflows.

Overview

A paid, time-boxed deployment of Ryniant on one real, active small-molecule discovery program to prove that a tissue delivery goal can be translated into an executable, closed-loop DMTA workflow.

You are not outsourcing R&D to us. Your team remains the scientific decision-maker and executes wet lab work as usual. We deploy/configure the platform, run the workflow, and deliver traceable outputs and measurable results.

Path

01

Pilot

Fixed scope, timeline, deliverables. Structured engagement with measurable outcomes.

02

LOI

Success triggers Phase 2 with metrics-based conversion. Down payment credited.

03

Scale

Expanded deployment across multiple programs, tissues, and deeper integration.

Requirements

Program

  • Active hit-to-lead / lead optimization pipeline
  • Defined primary tissue delivery goal (CNS, liver, kidney, tumor, ocular, etc.)
  • Pathway to generate assay data during pilot

Data

  • Starting compound list and known properties
  • Historical assay results or commitment to generate new ones
  • Data exchange method (CSV, shared drive, LIMS export)

Team

  • Scientific owner (med chem / program lead)
  • Comp chem/CADD contact
  • DMPK/ADMET or biology contact
  • Ops/data contact for exports

Scope

Included

One program, one tissue goal
Tissue filtering configuration
DMTA workflow orchestration
Compound prioritization
Assay ordering support
Results standardization
Human decision gates
Audit trail + documentation
Weekly readouts
Final results package

Optional Add-ons

Additional tissue goal
Additional assay panel
LIMS/ELN integration
Multi-team rollout

Not Included

We are not synthesizing compounds, running wet lab assays ourselves, or acting as the scientific approver. Program ownership stays with your team.

Phases

Week 0–1

Alignment + Baseline

Define tissue goal, map workflow, identify decision rules, establish baseline, confirm assay timeline.

Pilot Plan: scope + timeline + roles
Success Metrics Sheet with baselines
Decision Rule Specification
Week 1–2

Deployment + Configuration

Configure tissue filtering, assay standardization, governance gates, reporting formats.

Working DMTA workflow configured
Governance & audit setup
Dry run iteration validation
Week 2–8

Iterative DMTA Execution

Run real iterations: design → prioritize → test plan → results processing → learn → human approval.

Ranked candidate list + rationale
Assay order sheet
Results analysis memo
Decision log
Final Week

Final Evaluation

Compare performance vs baseline, identify bottlenecks, define Phase 2 scope and scaling plan.

Pilot Results Report
Rollout Proposal
LOI packet terms

Metrics

DMTA cycle time
Gluework reduction
Decision consistency
Time-to-configure
Iteration throughput

LOI Terms

LOI trigger tied to pre-agreed metrics. Includes Phase 2 scope, timeline, resourcing, and commercial terms. Down payment credited to Phase 2.

Apply

Schedule a call to discuss your program.